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Updated: Aug 7, 2025

Photogeneration of N-Heterocyclic Carbenes: Application in Photoinduced Ring-Opening Metathesis Polymerization
Published on: November 29, 2018
Construction of C(CO)-C(CO) Bond via NHC-Catalyzed Radical Cross-Coupling Reaction
Hai-Bin Yang1, Xiao-Fang Jin1, Hui-Ying Jiang1
1School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Abstract:
A C(sp2)-C(sp2) bond can be constructed via a photoredox/N-heterocyclic carbene (NHC)-cocatalyzed radical cross-coupling reaction, which provides a complementary strategy to classic electron pair processes. The present protocol represents the first example of an NHC-catalyzed two-component radical cross-coupling reaction involving C(sp2)-centered radical species. The decarboxylative acylation of oxamic acid with acyl fluoride was conducted under mild conditions and allowed the preparation of a variety of useful α-keto amides, including sterically congested ones.
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