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Updated: Aug 7, 2025
11:28
Designing, Packaging, and Delivery of High Titer CRISPR Retro and Lentiviruses via Stereotaxic Injection
Published on: May 23, 2016
17.7K
Biogenic materials for CRISPR delivery and therapeutics
Kaiyong Yang1, Jing Qian1, Chunli Zhang1
1Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China. xhan0220@njucm.edu.cn.
Biomaterials Science
|March 10, 2023
Summary
Biomimetic materials offer a safe and effective way to deliver CRISPR gene-editing technology for treating diseases. This review explores biomimetic delivery strategies for enhanced cellular uptake and gene editing efficiency.
Area of Science:
- Biotechnology
- Gene Editing
- Materials Science
Background:
- CRISPR gene-editing technology shows promise for genetic diseases and cancers.
- Efficient and safe delivery of CRISPR components remains a significant challenge.
- Biomimetic materials are emerging as a promising delivery strategy due to low immunogenicity and safety.
Purpose of the Study:
- To review current CRISPR/Cas delivery strategies utilizing biomimetic materials.
- To focus on the application of these strategies in disease research and therapy.
- To discuss the future prospects and limitations of CRISPR-based therapeutics.
Main Methods:
- Review of current literature on biomimetic materials for CRISPR delivery.
- Analysis of delivery strategies based on viruses, bacteria, cells, and bioactive substances.
- Evaluation of improvements in cellular uptake and gene editing efficiency.
Main Results:
- Biomimetic materials enhance cellular uptake of nanoparticle vectors.
- These materials improve the overall gene editing efficiency of CRISPR/Cas systems.
- Various biogenic materials are being explored for CRISPR delivery.
Conclusions:
- Biomimetic materials represent a significant advancement in safe and efficient CRISPR delivery.
- Further research is needed to overcome limitations and fully realize the therapeutic potential of CRISPR-based systems.
- These strategies hold promise for future disease research and treatment.
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