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Biologically active secoiridoids: A comprehensive update.

Zhongcan Peng1,2, Jun He1, Yungchi Cheng3

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Summary
This summary is machine-generated.

Secoiridoids, natural products with diverse bioactivities like neuroprotection and anti-tumor effects, are explored in this review. Discoveries from 2011-2020 highlight their potential for developing new drugs.

Keywords:
biological activitybiosynthesissecoiridoidsstructural diversitysynthesis

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Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Pharmacology

Background:

  • Secoiridoids are cyclopentane monoterpene derivatives with a unique hemiacetal structure.
  • They exhibit a broad spectrum of biological activities, including neuroprotective, anti-inflammatory, antidiabetic, hepatoprotective, and antinociceptive properties.
  • Phenolic secoiridoids show promise as precursors for antitumor drug development due to their action against tumorigenesis targets.

Purpose of the Study:

  • To provide a comprehensive review of naturally occurring secoiridoids.
  • To cover discoveries related to occurrence, structural diversity, bioactivities, and synthesis from January 2011 to December 2020.
  • To identify new avenues for pharmacological research and drug development based on secoiridoids.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of research on secoiridoid occurrence and structure.
  • Compilation of data on biological activities and synthesis pathways.

Main Results:

  • Detailed update on secoiridoid discoveries between 2011 and 2020.
  • Catalog of structural diversity and identified bioactivities.
  • Synthesis strategies and potential applications in drug development.

Conclusions:

  • Secoiridoids possess significant therapeutic potential across various medical fields.
  • Further research into their bioactivities and synthesis can lead to novel pharmaceutical agents.
  • This review serves as a foundation for future investigations into secoiridoid-based drug discovery.