Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective

Area of Science:

• Biochemistry
• Pharmacology
• Dermatology

Background:

• Wound healing is a complex process vital for tissue repair.
• Diabetes and obesity exacerbate wound complications, increasing healthcare burdens.
• Flavonoids are natural compounds with demonstrated anti-inflammatory, antioxidant, and pro-angiogenic properties.

Purpose of the Study:

• To review the evidence supporting the use of flavonoids in wound healing.
• To explore the molecular pathways modulated by flavonoids during skin repair.
• To discuss limitations and future perspectives for flavonoids as wound-healing agents.

Main Methods:

• Literature review of studies investigating flavonoid effects on wound healing.
• Analysis of flavonoid mechanisms of action on key signaling pathways.
• Synthesis of current data on flavonoid efficacy and safety.

Main Results:

• Flavonoids promote wound healing through anti-inflammatory, antioxidant, and pro-angiogenic effects.
• Flavonoids modulate critical signaling pathways including Wnt/β-catenin, TGF-β, and MAPK/ERK.
• Evidence suggests flavonoids can enhance re-epithelialization and barrier restoration.

Conclusions:

• Flavonoids represent a promising class of natural compounds for enhancing skin wound healing.
• Further research is needed to overcome current limitations and optimize their therapeutic application.
• Polyphenolic compounds offer a potential avenue for developing safe and effective wound-healing agents.