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Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

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Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical

Marta Kalbarczyk^1,2, Aleksandra Szcześ¹, Anna Belcarz³

¹Department of Interfacial Phenomena, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Skłodowska University, 20-031 Lublin, Poland.

Materials (Basel, Switzerland)

|March 11, 2023

Abstract:

In this study, calcium phosphate materials were obtained via a simple, eco-friendly wet synthesis method using hen eggshells as a calcium source. It was shown that Zn ions were successfully incorporated into hydroxyapatite (HA). The obtained ceramic composition depends on the zinc content. When doped with 10 mol % of Zn, in addition to HA and Zn-doped HA, DCPD (dicalcium phosphate dihydrate) appeared and its content increased with the increase in Zn concentration. All doped HA materials exhibited antimicrobial activity against S. aureus and E. coli. Nevertheless, fabricated samples significantly decreased preosteoblast (MC3T3-E1 Subclone 4) viability in vitro, exerting a cytotoxic effect which probably resulted from their high ionic reactivity.

Keywords:

Zn doping antibacterial activity calcium phosphate cytotoxicity eggshells hydroxyapatite calcium phosphate synthesis zinc doping bioceramics antimicrobial materials

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