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Related Concept Videos

Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
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Diabetes Mellitus: Overview and Type I Subtype01:22

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
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Insulin: Biosynthesis, Chemistry, and Preparation01:25

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The endoplasmic reticulum (ER) of pancreatic β-cells synthesizes preproinsulin, which consists of a signal peptide, A and B chains, and a C-peptide. Preproinsulin is then cleaved and folded into proinsulin, which translocates to the Golgi apparatus for sorting and packaging into secretory granules. In these granules, enzymatic clipping generates insulin and C-peptide.
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
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A Nanotechnology-Based Approach to Biosensor Application in Current Diabetes Management Practices.

Ambreen Shoaib1, Ali Darraj2, Mohammad Ehtisham Khan3

  • 1Department of Clinical Pharmacy, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.

Nanomaterials (Basel, Switzerland)
|March 11, 2023
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Early detection of diabetes mellitus is crucial. Nanotechnology-enhanced biosensors offer a promising, cost-effective solution for accurate diagnosis and monitoring, improving patient outcomes.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Diabetes mellitus presents significant short- and long-term health challenges, necessitating early detection.
  • Biosensors are increasingly vital for precise health diagnostics, aiding in diabetes management.
  • Nanotechnology advancements are enhancing biosensor performance, sensitivity, and disease detection capabilities.

Purpose of the Study:

  • To review the role of biosensors in diabetes mellitus diagnosis and management.
  • To explore the impact of nanotechnology on biosensor development for medical applications.
  • To discuss the evolution of glucose sensors and nano-biosensor technologies.

Main Methods:

  • Literature review focusing on biosensor types, glucose sensors, and nanotechnology applications.
  • Analysis of minimally invasive, invasive, and noninvasive biosensing technologies for glucose monitoring.
  • Examination of nanomaterial-based production processes for scalable biosensor development.

Main Results:

  • Biosensors, particularly those enhanced by nanotechnology, offer improved sensitivity and efficiency for disease detection.
  • Nanotechnology enables the development of novel nano-biosensors for accurate diabetes diagnosis and therapy monitoring.
  • Clinically efficient biosensors are user-friendly, cost-effective, and scalable.

Conclusions:

  • Nanotechnology-based biosensors hold transformative potential for diabetes care.
  • Further development is needed to overcome clinical practice hurdles for widespread adoption.
  • These advanced biosensors can significantly improve diabetes outcomes through early detection and monitoring.