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Progress in Biomaterials for Cardiac Tissue Engineering and Regeneration.
Alexandru Scafa Udriște1, Adelina-Gabriela Niculescu2,3, Luminița Iliuță1
1Department 4 Cardio-Thoracic Pathology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Polymers
|March 11, 2023
Summary
Biomaterial-based strategies show promise for cardiac tissue engineering and regeneration due to poor heart tissue repair. This review covers cardiac patches, hydrogels, extracellular vesicles, and scaffolds for improved cardiovascular disease treatments.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Cardiovascular Research
Background:
- Cardiovascular diseases are a major global health burden, driven by limited cardiac tissue regeneration and inadequate therapies.
- Current treatments for heart conditions face limitations due to the poor intrinsic repair capacity of adult cardiac tissues.
- There is a critical need for advanced therapeutic strategies to improve outcomes for cardiovascular diseases.
Purpose of the Study:
- To review the advantages of biomaterial-based approaches for cardiac tissue engineering and regeneration.
- To highlight recent advancements in biomaterial applications for treating cardiovascular diseases.
- To focus on key strategies including cardiac patches, injectable hydrogels, extracellular vesicles, and scaffolds.
Main Methods:
- Literature review of interdisciplinary research combining chemistry, biology, material science, medicine, and nanotechnology.
- Analysis of performant biomaterial-based structures designed for cardiac repair.
- Focus on four primary strategies: cardiac patches, injectable hydrogels, extracellular vesicles, and scaffolds.
Main Results:
- Biomaterial-based structures offer promising avenues for delivering cells and bioactive molecules to repair heart tissues.
- Recent developments show significant progress in cardiac patches, injectable hydrogels, extracellular vesicles, and scaffolds for cardiac regeneration.
- These interdisciplinary approaches leverage advances in multiple scientific fields to enhance therapeutic outcomes.
Conclusions:
- Biomaterial-based strategies represent a significant advancement in cardiac tissue engineering and regeneration.
- The reviewed approaches, including patches, hydrogels, vesicles, and scaffolds, offer enhanced therapeutic potential for cardiovascular diseases.
- Further research and development in these areas are crucial for overcoming the limitations of current treatments and reducing the burden of cardiovascular diseases.
