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Related Experiment Video

Updated: Aug 7, 2025

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Numerical Study of Particle Separation through Integrated Multi-Stage Surface Acoustic Waves and Modulated Driving

Yingqi Jiang^1,2, Jin Chen^1,2, Weipeng Xuan^1,2

¹Ministry of Education Key Laboratory of RF Circuits and Systems, College of Electronic & Information, Hangzhou Dianzi University, Hangzhou 310018, China.

Sensors (Basel, Switzerland)

|March 11, 2023

Summary

This study introduces multi-stage standing surface acoustic wave (SSAW) devices for efficient separation of multiple particle sizes. The novel approach significantly improves accuracy in fractionating biomedical particles like circulating tumor cells.

Keywords:

multi-stage sorting particle sorting standing surface acoustic waves

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Last Updated: Aug 7, 2025

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Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics

Published on: August 27, 2013

Area of Science:

Biomedical Engineering
Microfluidics
Acoustic Separation Technologies

Background:

Standing surface acoustic wave (SSAW) technology offers label-free and biocompatible methods for manipulating biomedical particles, including circulating tumor cell separation.
Current SSAW devices are limited to separating particles of only two distinct sizes, presenting a challenge for high-efficiency fractionation of multiple particle sizes.

Purpose of the Study:

To develop and investigate an integrated multi-stage SSAW device capable of fractionating various particle sizes with high efficiency and accuracy.
To address the limitations of single-stage SSAW devices in separating multiple cell populations.

Main Methods:

Design and analysis of a three-dimensional microfluidic device model using the finite element method (FEM).
Integration of multi-stage SSAW devices with varying wavelengths driven by modulated signals.
Systematic study of parameters including slanted angle, acoustic pressure, and resonant frequency on particle separation.

Main Results:

The proposed multi-stage SSAW device achieved a 99% separation efficiency for three different sized particles.
This efficiency represents a significant improvement over conventional single-stage SSAW devices.
FEM analysis provided insights into the effects of device geometry and acoustic properties on separation performance.

Conclusions:

Integrated multi-stage SSAW devices offer a promising solution for high-efficiency, high-accuracy separation of multiple particle sizes.
This technology has significant potential for applications in biomedical research and clinical diagnostics, such as improved cancer cell isolation.