Related Experiment Video
Updated: Aug 7, 2025

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro
Published on: June 2, 2018
[Age-specific morphophynctional features of pancreatic endocrine apparatus in rats.]
L A Sredneva1, J N Klyueva2, I F Gette1
1Institute of Immunology and Physiology, Ural Branch Russian Academy of Science, 106 Pervomajskaya str., Yekaterinburg 620049, Russian Federation,
Abstract:
Dysfunctions of endocrine organs play a priority role in the disruption of the regulation of normal functioning of the aging body. In the study age-related morphological and functional changes in the rat pancreatic insula apparatus have been investigated. With age fibrosis increased in both the pancreatic islets and exocrine pancreas. Non-functional hypertrophy of the islets, mainly due to the proliferation of connective tissue, was observed in rats under conditions of physiological aging. Immunohistochemical and biochemical studies revealed depletion of the islets insulin-producing function, development of hyperglycemia, accumulation of glycated proteins in the blood and change in oxidative stress indicators in 24-month-old rats.
More Related Videos
07:44Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation
Published on: August 7, 2015
10:49Confocal Laser Scanning Microscopy of Calcium Dynamics in Acute Mouse Pancreatic Tissue Slices
Published on: April 13, 2021
Related Concept Videos
Pancreas
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
Cells and Secretions of the Pancreas
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...