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Stimuli-responsive drug delivery systems triggered by intracellular or subcellular microenvironments
1Key Laboratory of Smart Drug Delivery (Ministry of Education), Minhang Hospital, State Key Laboratory of Medical Neurobiology, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, PR China.
Advanced Drug Delivery Reviews
|March 11, 2023
Summary
Stimuli-responsive drug delivery systems (DDS) leverage intracellular cues for targeted therapy. This review highlights advances in designing DDS that respond to the local microenvironment for enhanced drug release and reduced side effects.
Area of Science:
- Nanomedicine
- Biomedical Engineering
- Drug Delivery Systems
Background:
- Local microenvironment triggers are key in advanced nanomedicine.
- Intracellular and subcellular hallmarks offer precise disease targeting.
- Current stimuli-responsive drug delivery systems (DDS) face design challenges at microcosmic levels.
Purpose of the Study:
- To provide an overview of recent advances in stimuli-responsive DDS.
- To highlight the concept, design, preparation, and applications of these systems.
- To focus on systems functioning within intracellular models, rather than general targeting strategies.
Main Methods:
- Review of recent scientific literature on stimuli-responsive DDS.
- Analysis of systems triggered by intracellular or subcellular microenvironments.
- Focus on nanoplatforms operating at the cellular level.
Main Results:
- Stimuli-responsive DDS offer precise control over drug release kinetics.
- These systems can significantly reduce side effects by targeting diseased sites.
- Exploiting intracellular triggers expands the therapeutic window for nanomedicine.
Conclusions:
- Stimuli-responsive DDS triggered by the local microenvironment are a promising area of nanomedicine.
- Further development is needed to fully exploit DDS functioning at microcosmic levels.
- This review offers insights for developing advanced cellular-level nanoplatforms.
Keywords:
Drug delivery systemDrug release kineticsIntracellularMicroenvironmentStimuli-responsiveSubcellularMore Related Videos
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