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Updated: Aug 7, 2025

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
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TCF7L1 Accelerates Smooth Muscle Cell Phenotypic Switching and Aggravates Abdominal Aortic Aneurysms

Jing Wang1, Xiaoxiang Tian1, Chenghui Yan1

  • 1Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, China.

JACC. Basic to Translational Science
|March 13, 2023
PubMed
Abstract

Keywords:
AAA, abdominal aortic aneurysmAAV, adeno-associated virusAng II, angiotensin IICVF, collagen volume fractionMMP, matrix metalloproteinasePBS, phosphate-buffered salinePCR, polymerase chain reactionSM22α, smooth muscle protein 22-αSMA, smooth muscle actinSRF, serum response factorTCF7L1TCF7L1, transcription factor 7-like 1VSMC, vascular smooth muscle cellabdominal aortic aneurysmscDNA, complementary DNAmRNA, messenger RNAphenotypic switchingsiRNA, small interfering RNAsmooth muscle cell

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