Related Experiment Video

Updated: Aug 7, 2025

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
04:14

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution

Published on: April 16, 2019

12.0K

Liraglutide Lowers Endothelial Vascular Cell Adhesion Molecule-1 in Murine Atherosclerosis Independent of

Mukesh Punjabi1, Alexandra Kosareva1, Lifen Xu1

  • 1Cardiovascular Molecular Imaging, Department of Biomedicine, University of Basel, Basel, Switzerland.

JACC. Basic to Translational Science
|March 13, 2023
PubMed

Keywords:
ApoE, apolipoprotein ECEUMI, contrast-enhanced ultrasound molecular imagingCVD, cardiovascular diseaseGLP, glucagon-like peptideGLP-1R, glucagon-like peptide-1 receptorGLP-1RA, glucagon-like peptide-1 receptor agonistHDL-C, high-density lipoprotein cholesterolHbA1c, glycated hemoglobinICAM, intercellular cell adhesion moleculeIL, interleukinLDL-C, low-density lipoprotein cholesterolMB, microbubbleMBCtr, control microbubblesMBVCAM-1, microbubbles targeted to VCAMMCP, monocyte chemoattractant proteinOPN, osteopontinTG, triglyceridesTGRL, triglyceride-rich lipoproteinsTNF, tumor necrosis factorVCAM, vascular cell adhesion moleculeVLDL-C, very low-density lipoprotein cholesterolatherosclerosisliraglutidemolecular imagingultrasound

More Related Videos

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.6K
Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

9.8K

Related Concept Videos

Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
380
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
224