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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Visible light-induced oxidative α-hydroxylation of β-dicarbonyl compounds catalyzed by ethylenediamine-copper(ii)
Yujie He1, Hao Yin2, Yifeng Wang2
1College of Biological, Chemical Sciences and Engineering, Jiaxing University Jiaxing 314001 China chumingming@zjxu.edu.cn liyiming@zjxu.edu.cn.
Abstract:
We have developed an efficient oxidative α-hydroxylation of β-keto esters with firstly using the structurally simple ethylenediamine-copper(ii) as a catalyst for β-keto esters activation and using visible light as the driving force for generating more active singlet oxygen (1O2) from triplet state oxygen (3O2) in the air, providing a series of α-hydroxy β-keto esters in excellent yields (up to 99%) under extremely low photosensitizer loading (0.01 mol%) and catalyst loading (1 mol%) within a short time. Moreover, the gram-scale synthesis showed the practical utility of this protocol.
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