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GHRH-GH-IGF1 axis in pediatric Down syndrome: A systematic review and mini meta-analysis
David Shaki1,2, Eli Hershkovitz1,2, Shai Tamam3
1Pediatric Endocrinology Unit, Soroka University Medical Center, Beer Sheva, Israel.
Objective:
To analyze and determine the quality of functioning in different components of GHRH-GH-IGF1 axis in children with Down syndrome (DS).
Design:
Systematic review and mini meta-analysis of the literature.
Methods:
A search was performed in PubMed, Embase, Scopus, and PsycINFO through August 2022. Eligible studies included pediatric patients with DS who had undergone any laboratory evaluation of the GHRH-GH-IGF1 axis. Two reviewers independently screened articles for eligibility. Results of each type of test were weighed together in patients both with and without DS and were pooled using a random effects meta-analysis.
Results:
In total, 20 studies assessed the GHRH-GH-IGF1 axis function. A defect in three major components of GHRH-GH-IGF1 axis was found in a significant proportion of pediatric DS patients.
Conclusions:
A significant portion of short-stature pathogenesis in children with DS is associated with impaired GHRH-GH-IGF1 axis function.
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