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Updated: Aug 7, 2025

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry
Published on: November 25, 2011
Open photoacoustic cell for concentration measurements in rapidly flowing gas
János Fekete1, Péter Torma2,3, Anna Szabó1,2
1Department of Optics and Quantum Electronics, University of Szeged, H-6720 Szeged, Hungary.
Abstract:
High temporal resolution concentration measurements in rapid gas flows pose a serious challenge for most analytical instruments. The interaction of such flows with solid surfaces can generate excessive aero-acoustic noise making the application of the photoacoustic detection method seemingly impossible. Yet, the fully open photoacoustic cell (OC) has proven to be operable even when the measured gas flows through it at a velocity of several m/s. The OC is a slightly modified version of a previously introduced OC based on the excitation of a combined acoustic mode of a cylindrical resonator. The noise characteristics and analytical performance of the OC are tested in an anechoic room and under field conditions. Here we present the first successful application of a sampling-free OC for water vapor flux measurements.

