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Updated: Sep 6, 2026

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
Published on: February 10, 2023
Taming the Halogen Dance of Bromo(Thi)azoles through Flow Microreactors
Baran Ozveren1,2, Antoine Coeuillas1, Philippe Jubault1
1INSA Rouen Normandie, Univ. Rouen Normandie, Univ. Caen Normandie, ENSICAEN, CNRS, Institut CARMeN UMR 6064, F-76000Rouen, France.
Abstract:
Herein, we disclose a continuous-flow protocol for the lithiation of thiazoles, followed by a halogen dance rearrangement and subsequent trapping with diverse electrophiles. The transformation proceeds rapidly, occurring in less than 1 min, and exhibits broad applicability across a range of substrates, including oxazole and imidazole derivatives. The implementation of continuous-flow conditions provides enhanced control over reaction parameters and enables facile scale-up, thereby offering significant advantages for the development of streamlined and scalable synthetic methodologies.
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