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Related Experiment Videos

Large-bowel transit in paraplegic patients.

G Menardo1, G Bausano, E Corazziari

  • 1Divisione Medicina, Ospedale S Corona, Pietra Ligure, Italy.

Diseases of the Colon and Rectum
|December 1, 1987
PubMed
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Spinal cord injury causes severe constipation due to abnormal large bowel transit, primarily affecting the left colon and rectum. This impacts motor activity, particularly in segments controlled by sacral parasympathetic nerves.

Area of Science:

  • Neurogastroenterology
  • Spinal Cord Injury Research
  • Colorectal Physiology

Background:

  • Severe constipation is a common complication following spinal cord injury (SCI).
  • Paraplegia, resulting from complete transverse spinal cord lesions, significantly affects bowel function.
  • Understanding the mechanisms of constipation in SCI is crucial for patient management.

Purpose of the Study:

  • To evaluate colonic and rectal transit in patients with paraplegia due to SCI.
  • To compare bowel transit in paraplegic patients with healthy individuals.
  • To identify the specific regions of the large bowel affected by SCI-induced constipation.

Main Methods:

  • Colonic transit study involving 11 patients with paraplegia (complete transverse spinal cord lesion).

Related Experiment Videos

  • Evaluation of transit through the right colon, left colon, and rectum.
  • Comparison of patient data with 37 healthy control subjects.

    • Main Results:

    • All paraplegic patients exhibited absent or significantly reduced transit in the left colon and rectum.
    • Eight patients showed a minor delay in right colon transit.
    • SCI-induced constipation is primarily linked to impaired left colon and rectal motility.

    Conclusions:

    • Constipation in paraplegia is predominantly caused by abnormal transit in the left colon and rectum.
    • Spinal cord transection (C-4 to T-12) alters large bowel motor activity.
    • The sacral parasympathetic outflow's innervated segments are mainly affected, leading to bowel dysfunction.