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Updated: Aug 7, 2025

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
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Cerebellar Excitability Regulates Physical Fatigue Perception.

Agostina Casamento-Moran1, Ronan A Mooney1, Vikram S Chib2,3

  • 1Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, Maryland 21287.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|March 13, 2023
PubMed
Summary
This summary is machine-generated.

Decreased cerebellar excitability after fatiguing tasks correlates with reduced fatigue perception but may impair motor control. This suggests the cerebellum plays a role in how we experience and manage physical exertion.

Keywords:
TMScerebellumfatigabilityfatigueinteroceptionmotor control

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Area of Science:

  • Neuroscience
  • Human Physiology
  • Motor Control

Background:

  • Fatigue is a common, debilitating symptom in many illnesses, yet its neurophysiological underpinnings are poorly understood.
  • The cerebellum, traditionally linked to motor control, is increasingly recognized for its role in perceptual processes.
  • The cerebellum's specific contribution to the sensation of fatigue remains largely unexplored.

Purpose of the Study:

  • To investigate whether cerebellar excitability is altered following a fatiguing task.
  • To examine the association between changes in cerebellar excitability and the perception of fatigue.
  • To explore the behavioral consequences of altered cerebellar excitability on motor performance after fatigue.

Main Methods:

  • Two experiments using a crossover design with 33 participants.
  • Measurement of cerebellar inhibition (CBI) and fatigue perception before and after fatiguing and control tasks.
  • Assessment of motor performance using a ballistic goal-directed task in the second experiment.

Main Results:

  • Reduced CBI after the fatiguing task was correlated with a milder perception of fatigue.
  • Greater endpoint variability in motor tasks after fatigue correlated with reduced CBI.
  • These findings indicate a proportional relationship between cerebellar excitability and fatigue perception.

Conclusions:

  • The cerebellum is implicated in the perception of fatigue.
  • Altered cerebellar excitability may influence both fatigue sensation and motor control.
  • Fatigue and motor performance may compete for cerebellar resources.