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Updated: Aug 7, 2025
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A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
Published on: July 4, 2017
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Predicting Deformity Correction of Growth Modulation in Late-onset Tibia Vara.
Janet L Walker1, David M Dueber2, Kenneth P Powell3
1Shriners Children's and University of Kentucky Department of Orthopaedic Surgery and Sports Medicine.
Journal of Pediatric Orthopedics
|March 13, 2023
Summary
Growth modulation for late-onset tibia vara (LOTV) is less successful with severe deformity, hip physeal closure, or weight over 100 kg. These factors help predict outcomes for tension band procedures.
Area of Science:
- Orthopedics
- Pediatric Orthopedics
- Skeletal Dysplasias
Background:
- Late-onset tibia vara (LOTV) growth modulation outcomes are variable.
- Predictive factors for successful LOTV treatment remain unclear.
Purpose of the Study:
- To identify predictors of successful growth modulation in LOTV.
- To evaluate the impact of deformity severity, skeletal maturity, and body weight on treatment outcomes.
Main Methods:
- Retrospective review of 54 patients (76 limbs) undergoing tension band growth modulation for LOTV.
- Radiographic assessment of tibial and limb alignment (MPTA, mTFA) and physeal maturity.
- Logistic regression analysis to determine outcome predictors.
Main Results:
- Decreased preoperative medial proximal tibia angle (MPTA) and increased mechanical tibiofemoral angle (mTFA) reduced success odds.
- Proximal femoral physeal closure significantly decreased success odds for both first lateral tibial tension band plating (LTTBP) and growth modulation series (GMS).
- Preoperative weight ≥100 kg significantly decreased GMS success odds for mTFA.
Conclusions:
- Deformity magnitude, hip physeal closure, and body weight ≥100 kg negatively impact LOTV growth modulation success.
- A predictive model using these variables can guide treatment decisions.
- Growth modulation may still be beneficial in high-risk patients to reduce deformity.
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