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Related Experiment Video

Updated: Aug 7, 2025

Author Spotlight: Single-Molecule Surface-Enhanced Raman Scattering Measurements Enabled by Plasmonic DNA Origami Nanoantennas
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DNA-Guided One-Dimensional Plasmonic Nanostructures for the SERS Bioassay.

Huan Liang1, Lingling Jiang1, Hongying Li1

  • 1Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University) Ministry of Education; College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.

ACS Sensors
|March 14, 2023
PubMed
Summary

Researchers developed a DNA-guided method to create ordered plasmonic nanostructures for enhanced surface-enhanced Raman scattering (SERS). This technique improves SERS assays for detecting biomarkers like microRNA-155, aiding early cancer diagnosis.

Keywords:
DNASERSmicroRNAone-dimensionalplasmonic

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Area of Science:

  • Nanotechnology
  • Biotechnology
  • Analytical Chemistry

Background:

  • Surface-enhanced Raman scattering (SERS) is highly sensitive to the precise spacing of plasmonic nanostructures.
  • Achieving controlled interparticle distances in nanostructures for optimal SERS remains a significant challenge.
  • DNA's specific recognition and modification capabilities offer potential for precise nanostructure assembly.

Purpose of the Study:

  • To develop a DNA-guided self-assembly method for creating ordered plasmonic nanostructures.
  • To enhance the stability and sensitivity of SERS assays through controlled nanostructure spacing.
  • To establish a novel SERS-based strategy for the detection of microRNA-155 (miRNA-155) for early cancer diagnosis.

Main Methods:

  • Utilized DNA-guided gold nanoparticles to form one-dimensional ordered structures.
  • Employed a bottom-up self-assembly approach at the water-oil interface.
  • Implemented an output switching strategy to amplify target DNA for reporter DNA transfer.
  • Captured Raman probes on the sensing interface for SERS assay.

Main Results:

  • Successfully formed DNA-guided, one-dimensional ordered gold nanoparticle structures.
  • Demonstrated the ability to precisely control interparticle spacing using DNA.
  • Achieved sensitive SERS detection of microRNA-155 (miRNA-155) via an amplification strategy.
  • Validated the potential for clinical surveillance and early cancer diagnosis.

Conclusions:

  • DNA-guided self-assembly provides an effective strategy for creating ordered plasmonic nanostructures.
  • Controlled nanostructure spacing significantly enhances SERS performance.
  • The developed SERS assay offers a promising tool for sensitive miRNA detection and early cancer diagnostics.