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Limited Clinical Value of Anti-Retinal Antibody Titers and Numbers in Autoimmune Retinopathy
Ploysai Rujkorakarn1,2,3, Michael J Margolis1,2, Diana Morvey1,2
1Massachusetts Eye Research and Surgery Institution, Waltham, MA, USA.
Purpose:
To assess the possible correlation of anti-retinal antibody titers and number of anti-retinal antibodies with outcome measurements including visual acuity, subjective vision loss, visual field, and electroretinography in patients with autoimmune retinopathy.
Design:
Single-center, retrospective cross-sectional study.
Patients And Methods:
Patients with autoimmune retinopathy who underwent anti-retinal antibody testing at least twice during their follow-up were enrolled. Anti-retinal antibody titers and numbers were grouped as improved, stable, or worsened. Outcomes included Snellen visual acuity, patient-reported vision loss, Humphrey visual field mean deviations, and electroretinography parameters.
Results:
Thirty-one eyes among 16 patients with autoimmune retinopathy were included. Between-group analyses of visual acuity, subjective vision loss, visual field, and electroretinography outcomes did not reveal any significant differences by anti-retinal antibody titer or number group at a 95% confidence interval.
Conclusion:
Changes in anti-retinal antibody titers or numbers were not associated with any vision outcome. Repeated anti-retinal antibody testing may be unnecessary after diagnosis of autoimmune retinopathy and detection of an anti-retinal antibody.
