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A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

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Knowledge mapping of interleukin-33: a bibliometric study.

Jingchao Sun¹, Yu Xia¹, Dandan Zhang¹

¹Shandong University of Traditional Chinese Medicine Jinan 250000, Shandong, China.

American Journal of Translational Research

|March 14, 2023

Summary

This summary is machine-generated.

Interleukin-33 (IL-33) is a key cytokine involved in immune responses and tissue repair. Research highlights its significant role in various diseases, particularly allergic conditions, driving therapeutic development.

Keywords:

Citespace IL-33 bibliometric analysis cytokines visualization vosviewer

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Area of Science:

Immunology
Molecular Biology
Biochemistry

Background:

Interleukin-33 (IL-33) is an IL-1 family cytokine linked to tissue damage and immune cell receptor expression.
IL-33 is crucial for immune amplification and regulation in type 2 innate immune responses and allergic inflammation.
IL-33 is implicated in inflammation-related diseases, including allergies, autoimmune disorders, infections, and cancers, while also supporting tissue homeostasis and repair.

Purpose of the Study:

To analyze the global research landscape of Interleukin-33 (IL-33) from 2005 to 2021.
To identify key trends, influential publications, and research hotspots concerning IL-33's role in various diseases.
To understand the significance of IL-33 in immune regulation and its therapeutic potential.

Main Methods:

Bibliometric analysis of 2626 publications from the Web of Science Core Collection (WoSCC).
Data processing and visualization using Microsoft Excel, VOSviewer, and Citespace.
Analysis of countries/regions, journals, authors, co-cited references, and keywords.

Main Results:

IL-33 is a significant cytokine with a prominent role in numerous diseases, especially allergic diseases.
The analysis identified key research areas and collaborations related to IL-33.
Bibliometric data revealed the growing importance and impact of IL-33 research.

Conclusions:

IL-33 plays a critical role in immune responses and disease pathogenesis, particularly in allergic conditions.
Further investigation into IL-33's mechanisms is vital for developing novel therapeutic strategies.
This bibliometric study provides a comprehensive overview of IL-33 research trends and impact.