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Methylergometrine antagonizes 5 HT in the temporal artery
P Tfelt-Hansen1, I Jansen, L Edvinsson
1Department of Neurology, Rigshospitalet, Copenhagen, Denmark.
European Journal of Clinical Pharmacology
|January 1, 1987
Abstract:
Methylergometrine, the main metabolite of methysergide, has 40-times greater 5 HT antagonistic potency than methysergide in isolated segments of human temporal artery. It is suggested that methylergometrine is the "active" drug when methysergide is used in migraine prophylaxis, and that the two compounds should be compared in prophylactic trials in migraine.