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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Differential Staining Technique01:26

Differential Staining Technique

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Differential staining is an essential microbiological technique that exploits variations in cell wall structures to classify and identify microorganisms. It facilitates the distinction of bacteria, aiding in diagnostic and research applications. Two of the most widely used differential staining methods are Gram staining and acid-fast staining, both of which rely on the chemical and structural differences in bacterial cell walls.Gram Staining TechniqueGram staining differentiates bacteria by...
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
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Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
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Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Updated: Aug 7, 2025

Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
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Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses

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[Differential diagnoses severe skin infections].

Camille Hua1, Olivier Chosidow2

  • 1Service de dermatologie, hôpital Henri-Mondor, Créteil, France.

La Revue Du Praticien
|March 14, 2023
PubMed
Summary
This summary is machine-generated.

Necrotizing soft tissue infections require urgent surgical treatment. Recognizing key differential diagnoses like pyoderma gangrenosum is crucial, as surgical intervention can worsen certain conditions.

Keywords:
ErysipelasNecrosisSoft Tissue Infections

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Area of Science:

  • Infectious Diseases
  • Dermatology
  • Surgical Pathology

Context:

  • Necrotizing soft tissue infections (NSTI) present diagnostic challenges.
  • Accurate diagnosis is critical due to the need for urgent surgical intervention.
  • Differential diagnoses include non-necrotizing infections, pyoderma gangrenosum, and vascular emergencies.

Purpose:

  • To outline the differential diagnoses for severe skin infections, specifically necrotizing soft tissue infections.
  • To emphasize the importance of distinguishing NSTI from other conditions with similar presentations.
  • To highlight the potential negative impact of surgical intervention on specific differential diagnoses, such as pyoderma gangrenosum.

Summary:

  • Necrotizing soft tissue infection (NSTI) diagnosis is clinically challenging and requires surgical confirmation and urgent treatment.
  • Key differential diagnoses include non-necrotizing soft tissue infections, pyoderma gangrenosum, acute leg ischemia, compartment syndrome, and diabetic foot infections.
  • Misdiagnosis can lead to inappropriate management, with surgery potentially exacerbating conditions like pyoderma gangrenosum.

Impact:

  • Improved diagnostic accuracy for severe skin infections.
  • Optimized treatment strategies by differentiating NSTI from its mimics.
  • Reduced risk of iatrogenic harm from unnecessary or contraindicated surgical procedures.