Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gas Chromatography: Types of Detectors-II

Gas Chromatography: Types of Detectors-II

In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Per- and Polyfluoroalkyl Substances and Total Organic Fluorine Ratios from Field-Collected Light Nonaqueous Phase Liquids and Groundwater.

Environmental science & technology·2026

Same author

Correction to "Biomimetic Chromatography: A Novel Approach for Measuring Phospholipid Membrane-Water and Protein-Water Partition Coefficients for Target and Suspect PFAS".

Environmental science & technology·2026

Same author

In Situ NMR Tube Extraction Reveals Increased Fluorine Release with Polymer Swelling.

Analytical chemistry·2026

Same author

Biomimetic Partitioning and Pharmacokinetic Insights into Phytocannabinoids.

ACS omega·2026

Same author

Challenges and Opportunities in PFAS Waste Management for Semiconductor Manufacturing.

Environmental science & technology·2026

Same author

Biomimetic Chromatography: A Novel Approach for Measuring Phospholipid Membrane-Water and Protein-Water Partition Coefficients for Target and Suspect PFAS.

Environmental science & technology·2025

Search research articles

Related Experiment Video

Updated: Aug 6, 2025

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Published on: April 18, 2019

Evaluating Neutral PFAS for Potential Dermal Absorption from the Gas Phase.

John C Kissel¹, Ivan A Titaley², Derek J Muensterman³

¹Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, United States.

Environmental Science & Technology

|March 14, 2023

Summary

Dermal absorption of neutral per- and polyfluoroalkyl substances (PFAS) may be significant. This study estimates dermal absorption, suggesting it

Keywords:

dermal absorption dermal-to-inhalation ratio gas phase neutral PFAS stratum corneum-to-gas phase partitioning coefficient transdermal permeability coefficients

More Related Videos

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Published on: September 28, 2022

Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets

Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets

Published on: October 15, 2021

Related Experiment Videos

Last Updated: Aug 6, 2025

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Published on: April 18, 2019

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

Published on: September 28, 2022

Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets

Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets

Published on: October 15, 2021

Area of Science:

Environmental Chemistry
Toxicology
Occupational Health

Background:

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous environmental contaminants.
Current exposure assessments primarily consider ingestion and inhalation routes.
Dermal absorption of neutral PFAS, especially from vapor, remains understudied.

Purpose of the Study:

To estimate the potential for dermal absorption of neutral PFAS.
To compare dermal absorption to inhalation exposure for neutral PFAS.
To identify neutral PFAS where dermal absorption may be a significant exposure pathway.

Main Methods:

Utilized SPARC-estimated physicochemical properties to calculate transdermal permeability coefficients (kp_g).
Calculated dermal-to-inhalation (D/I) exposure ratios for neutral PFAS.
Assessed two groups of neutral PFAS, including those on an EPA PFAS list.

Main Results:

Calculated D/I ratios exceeded 5 for 11 neutral PFAS.
These findings suggest transdermal absorption may be a critical exposure route for these compounds.
The study highlights the need to consider dermal uptake in overall PFAS risk assessment.

Conclusions:

Neutral PFAS can be absorbed through the skin, potentially contributing significantly to overall exposure.
Further research, including data on consumer products and indoor air, is needed to verify these findings.
Biomonitoring may be necessary to experimentally confirm dermal absorption from air for key neutral PFAS.