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Arterial stiffness and its associations with left ventricular diastolic function according to heart failure types

Hack-Lyoung Kim1, Jaehoon Chung2, Seokmoon Han3

  • 1Division of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea. khl2876@gmail.com.

Clinical Hypertension
|March 15, 2023
PubMed

Insights

Arterial stiffness is elevated in heart failure (HF) patients, with similar levels in both reduced (HFrEF) and preserved (HFpEF) ejection fraction groups. The link between stiffness and diastolic function is weaker in HF patients.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Physiology
  • Heart Failure Research

Background:

  • Arterial stiffness characteristics in heart failure (HF) remain largely unknown.
  • This study investigates arterial stiffness and its relationship with left ventricular (LV) diastolic function in HF patients.

Purpose of the Study:

  • To compare arterial stiffness (using brachial-ankle pulse wave velocity, baPWV) between control subjects, patients with HF with reduced ejection fraction (HFrEF), and patients with HF with preserved ejection fraction (HFpEF).
  • To examine the association between arterial stiffness and LV diastolic function in these groups.

Main Methods:

  • Analysis of 83 HFrEF patients, 68 HFpEF patients, and 84 control subjects.
  • Measurements included brachial-ankle pulse wave velocity (baPWV) and transthoracic echocardiography.
  • All HF patients had a history of HF hospitalization and were studied in a stable condition.

Main Results:

  • baPWV was significantly higher in both HFrEF and HFpEF groups compared to controls.
  • Adjusted for age, baPWV levels were similar between HFrEF and HFpEF groups.
  • baPWV was significantly associated with septal e' velocity and E/e' in the overall HF group, but these associations were attenuated or absent within specific HF subtypes.

Conclusions:

  • Arterial stiffness is increased in HF patients, but its association with LV diastolic function is attenuated compared to controls.
  • The degree of arterial stiffening is comparable between HFrEF and HFpEF.
  • Findings highlight differences in vascular-cardiac coupling between HF subtypes.
Abstract

Keywords:
Diastolic functionHeart failurePulse wave analysisVascular stiffness

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