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Updated: Aug 6, 2025

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
Published on: September 15, 2018
[A Family History of Hypercholesterolemia - the Role of Genetics]
Clara Podmore1, Eva Deillon1, David Nanchen1
1Consultation de prévention cardiovasculaire, cholestérol et style de vie, Département promotion de la santé et préventions, Centre universitaire de médecine générale et santé publique, Unisanté, Université de Lausanne, Lausanne, Suisse.
Abstract:
A Family History of Hypercholesterolemia - the Role of Genetics Abstract. Genetic testing is rarely used in Switzerland to confirm the clinical diagnosis of familial hypercholesterolemia. However, cascade genetic testing from an index case is recommended by the guidelines. By describing a patient and his family with severe hypercholesterolemia, we discuss the benefits, risks and barriers regarding the implementation of genetics for familial hypercholesterolemia. Family screening with genetic testing could become a standard of care for severe hypercholesterolemia.
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