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Underlying causes and outcomes of recurrent pneumonia in hospitalized children

Mei Mei1, Dan Dai1, Zhuoyao Guo1

  • 1Department of Respiratory Medicine, Children's Hospital of Fudan University, Shanghai, China.

Pediatric Pulmonology
|March 15, 2023
PubMed

Insights

Recurrent pneumonia in children often has underlying causes like aspiration and primary immunodeficiency. Identifying these causes and risk factors is crucial for managing severe outcomes and rehospitalization.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Medicine
  • Genetics

Background:

  • Recurrent pneumonia (RP) in hospitalized children presents a significant clinical challenge.
  • Understanding the underlying causes and risk factors for adverse outcomes is essential for effective management.

Approach:

  • A retrospective review of medical records for hospitalized children diagnosed with RP was conducted.
  • Logistic regression analysis was used to identify associations between various factors and adverse outcomes.

Key Points:

  • The majority of children (87.7%) with RP had identifiable underlying causes, most commonly recurrent aspiration, primary immunodeficiency (PID), and congenital heart diseases.
  • Genetic defects were identified in 28.7% of patients.
  • Risk factors for severe outcomes included PID, primary ciliary dyskinesia, bronchiolitis obliterans, and RP diagnosis after age 3.
  • Aspiration and abnormal family history were risk factors for rehospitalization.

Conclusions:

  • Underlying causes are prevalent in hospitalized children with recurrent pneumonia.
  • Genetic factors play a notable role in the etiology of RP.
  • Identifying specific risk factors aids in predicting and mitigating severe outcomes and rehospitalization.
Abstract

Keywords:
genetic conditionoutcomerecurrent pneumoniaunderlying causes

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