Related Experiment Video
Updated: Aug 6, 2025
08:56
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
2.8K
Kimyrsa and Orbactiv - A Tale of Two Formulations
Brittany T Jackson1, David B Cluck2, Andrés F Henao-Martínez3
1Department of Pharmacy, Mount Sinai Morningside, New York, NY, 10025, USA.
Drug Design, Development and Therapy
|March 16, 2023
Summary
Kimyrsa, a new oritavancin formulation, offers shorter infusion times and better solution compatibility. Its pharmacokinetic and microbiologic profiles are similar to the original formulation, with limited real-world data currently available.
Area of Science:
- Pharmacology
- Infectious Diseases
- Clinical Pharmacy
Background:
- Oritavancin is a lipoglycopeptide antibiotic used for Gram-positive bacterial infections.
- A new formulation (NF) of oritavancin has been developed, distinct from the original formulation (OF).
Purpose of the Study:
- To compare the new formulation (NF) of oritavancin with its original formulation (OF).
- To evaluate the potential benefits and clinical utility of the new oritavancin formulation.
Main Methods:
- Comparative analysis of formulation characteristics.
- Review of pharmacokinetic and microbiologic profiles.
- Assessment of clinical data and real-world experience.
Main Results:
- The new formulation (NF) offers a shortened infusion time and enhanced solution compatibility compared to the original formulation (OF).
- Pharmacokinetic and microbiologic profiles remain largely similar between the NF and OF.
- Limited real-world experience currently exists for the NF.
Conclusions:
- The new oritavancin formulation provides practical advantages in administration.
- Its therapeutic role is anticipated to be comparable to the original formulation, pending further real-world data.
- Further clinical experience is needed to fully establish the NF's place in therapy among lipoglycopeptides.
Related Concept Videos
01:16Bioequivalence: Overview
1.1K
Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
1.1K
01:16Methods for Studying Drug Absorption: In vitro
276
In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
276
01:09Peripherally and Centrally Acting Muscle Relaxants: A Comparison
3.5K
Skeletal muscle relaxants can target the central nervous system [CNS] to reduce muscle tension or act directly at the neuromuscular junction to induce temporary paralysis. These two classes of muscle relaxants are called centrally acting muscle relaxants and peripherally acting muscle relaxants. They differ in their action, mechanism, administration route, and clinical uses.
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic...
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic...
3.5K
01:09Methods for Studying Drug Absorption: In situ
288
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
288
01:26Pharmacokinetic Models: Comparison and Selection Criterion
118
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
118
01:21Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
1.6K
Drug absorption within the gastrointestinal (GI) tract is a complex process influenced by several critical factors, including the site pH, the drug's dissociation constant (pKa), and the drug's lipophilicity. The GI tract exhibits a pH gradient, with an acidic environment in the stomach and a more alkaline environment in the small intestine. This pH variation directly affects the ionization state of drugs.
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
1.6K