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Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
Published on: May 17, 2024
Solitary giant neurofibroma of the knee: a case report
Adnane Lachkar1, Amine El Farhaoui1, Abdeljaouad Najib1
1Department of Orthopedic Surgery B, Hospital University Center Mohammed VI, Oujda, Morocco.
Abstract:
Solitary neurofibroma is a rare tumor that occurs particularly in the head and trunk. It is mostly small and rarely exceeds 2 cm.
Case Report:
A 61-year-old female patient complained about an increasingly extended mass with pain in the right knee for about 14 months. Physical examination reveals a big, solid mass in front of the medial condyle, measuring about 14×12 cm. Tinel's sign was positive on mass percussion. MRI showed a well-circumscribed oval mass with low signal on T1 and high signal on T2-weighted images. A surgical biopsy was performed, and immunohistochemistry confirmed the diagnosis of solitary neurofibroma. Surgical excisions were performed with good outcomes.
Discussion:
A giant solitary neurofibroma is exceptional. The knee location is even rarer. Immunohistochemistry is the only way to confirm the diagnosis.
Conclusion:
Giant neurofibromas need a complete surgical excision. Until today, there were no other alternative therapies for these tumors.

