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Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Cortical and thalamic inputs drive distinct hippocampal microcircuits to modulate synchronized activity during

Vincent Robert¹, Tanvi Butola¹, Jayeeta Basu²

¹Neuroscience Institute, New York University Langone Health, New York, NY 10016, USA.

|March 16, 2023

Summary

Early synchronized brain activity in the hippocampus, crucial for network development, is driven by cortical inputs in living animals. This contrasts with lab experiments showing modulation by both cortical and thalamic inputs.

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Functional Calcium Imaging in Developing Cortical Networks

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Last Updated: Aug 6, 2025

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

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Published on: June 29, 2018

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

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Functional Calcium Imaging in Developing Cortical Networks

Functional Calcium Imaging in Developing Cortical Networks

Published on: October 22, 2011

Area of Science:

Neuroscience
Developmental Neuroscience
Hippocampal Network Dynamics

Background:

Synchronized neural activity is a key feature of hippocampal network function.
This synchronized activity emerges early in brain development.
The role of extrinsic inputs in driving this early activity is not well understood.

Purpose of the Study:

To investigate the role of extrinsic inputs in driving early synchronized activity in the hippocampus.
To compare the influence of cortical and thalamic inputs on hippocampal network dynamics in vivo and ex vivo.

Main Methods:

Electrophysiological recordings in vivo and ex vivo.
Perturbation of cortical and thalamic inputs.

Main Results:

In vivo, synchronized hippocampal activity depends exclusively on cortical inputs.
Ex vivo, synchronized activity is modulated by both cortical and thalamic inputs.
This highlights a difference in input-driven network dynamics between in vivo and ex vivo preparations.

Conclusions:

Cortical inputs are essential for driving early synchronized hippocampal activity in a developing brain.
The distinct findings in vivo and ex vivo suggest different mechanisms underlying network synchronization depending on the experimental context.