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Related Experiment Video

Updated: Aug 6, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Electrically regulated cell-based intervention for viral infections.

Sherri Newmyer¹, Marvin A Ssemadaali¹, Harikrishnan Radhakrishnan¹

¹Biosciences Division SRI International Menlo Park California USA.

Bioengineering & Translational Medicine

|March 17, 2023

Summary

This summary is machine-generated.

Engineered cells, ES-Biofactory, synthesize interferon-beta upon electrical stimulation for a universal antiviral therapy. This novel platform offers rapid deployment against pandemics and potential treatment for other diseases.

Keywords:

cell engineering cell therapies electrogenetics synthetic biology viral infections

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Area of Science:

Synthetic Biology
Cell Engineering
Antiviral Therapeutics

Background:

Emerging pandemics necessitate rapid, broad-spectrum antiviral interventions.
Existing viral countermeasures can be hindered by viral interference with natural pathways.

Purpose of the Study:

To engineer a mammalian cell-based platform (ES-Biofactory) for rapid, inducible protein synthesis.
To develop a universal antiviral therapy using engineered interferon-beta (IFN-β).

Main Methods:

Mammalian cells engineered with synthetic elements: voltage-gated Ca2+ channel, Ca2+-mediated signaling pathway, and engineered IFN-β transgene.
Electrical stimulation to activate the synthetic pathway and induce IFN-β production.
Validation of antiviral effects against SARS-CoV-2 and assessment of oncogenic capacity.

Main Results:

The ES-Biofactory successfully synthesized IFN-β upon electrical stimulation.
Engineered IFN-β demonstrated antiviral effects against SARS-CoV-2.
Irradiated ES-Biofactory cells retained antiviral activity and showed no oncogenic capacity.

Conclusions:

The ES-Biofactory platform provides a novel, inducible system for producing antiviral proteins.
This cell therapy offers a potentially rapid and deployable pan-viral intervention.
The platform shows promise for treating viral infections, cancer, and autoimmune disorders.