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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

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Overview
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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[Documentation of biological treatment in asthma].

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Sensitization profiles in patients with wheat-dependent exercise-induced anaphylaxis: practical aspects for allergy workup.

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Diagnosis and treatment of Hymenoptera venom allergy: S2k Guideline of the German Society of Allergology and Clinical Immunology (DGAKI) in collaboration with the Arbeitsgemeinschaft für Berufs- und Umweltdermatologie e.V. (ABD), the Medical Association of German Allergologists (AeDA), the German Society of Dermatology (DDG), the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery (DGHNOKC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Allergy and Environmental Medicine (GPA), German Respiratory Society (DGP), and the Austrian Society for Allergy and Immunology (ÖGAI).

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Liebe Leserinnen und Leser.

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Related Experiment Video

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Basophil Activation Test for Allergy Diagnosis
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Allergic asthma: An indication for allergen immunotherapy.

Tobias Ankermann1, Randolf Brehler1,2

  • 1Childrens Hospital, Städtisches Krankenhaus Kiel gGmbH, Kiel, and.

Allergologie Select
|March 17, 2023
PubMed
Summary
This summary is machine-generated.

Allergen immunotherapy (AIT) effectively modifies disease progression for allergic rhinitis and asthma. Evidence confirms AIT’s efficacy in treating allergic asthma, addressing underlying inflammatory mechanisms.

Keywords:
allergen-specific immunotherapy (AIT)allergic asthmaasthmaenvironmental allergensmeta-analyses

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Area of Science:

  • Immunology
  • Allergy and Clinical Immunology
  • Respiratory Medicine

Background:

  • Allergen immunotherapy (AIT) is a recommended disease-modifying treatment for allergic rhinitis and asthma.
  • Standardization and clinical trials validate AIT efficacy, with real-world evidence supporting findings.
  • Allergic rhinitis and asthma share inflammatory pathways, making AIT a relevant therapeutic approach.

Purpose of the Study:

  • To summarize the evidence for the efficacy of allergen immunotherapy (AIT) in treating allergic asthma.
  • To highlight AIT's role in addressing the underlying mechanisms of interrelated respiratory diseases.

Main Methods:

  • Review of randomized clinical trials and real-world evidence studies on AIT for allergic respiratory diseases.
  • Focus on trials investigating AIT's effects on allergic asthma parameters.
  • Synthesis of data to assess AIT's efficacy in allergic asthma indication.

Main Results:

  • Robust data support AIT's efficacy in allergic rhinitis treatment.
  • Growing evidence indicates AIT's effectiveness in managing allergic asthma.
  • AIT demonstrates potential in modifying the course of both allergic rhinitis and asthma.

Conclusions:

  • Allergen immunotherapy is a validated treatment for allergic rhinitis and asthma.
  • The evidence supports the use of AIT for allergic asthma, targeting core disease mechanisms.
  • AIT offers a disease-modifying approach for patients with these interconnected respiratory conditions.