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Updated: Aug 6, 2025

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Published on: March 3, 2023
Clinical endpoints in allergen immunotherapy: State of the art 2022
Roy Gerth van Wijk1, Ludger Klimek2, Oliver Pfaar3
1Section of Allergology and Clinical Immunology, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.
Abstract:
110 years after the classical study by Noon, numerous studies have confirmed the efficacy of allergen immunotherapy. A variety of clinical endpoints have been used in these trials. This review gives an overview of clinical endpoints for randomized clinical trials on allergen immunotherapy (AIT) in rhinitis and asthma. In addition, real-life studies have been carried out with the same kind of endpoints. In general, AIT studies are characterized by a lack of standardized and validated outcome measures. For allergic rhinoconjunctivitis, digital tools have been developed to monitor patients. Such tools are particularly useful to obtain real-world evidence for AIT. Finally, well-accepted outcome measures are available for cost-effectiveness studies.
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