Using a Network Physiology Approach to Prescribe Exercise for Exercise Oncology.
1Department of Kinesiology, The Pennsylvania State University, University Park, PA, United States.
Frontiers in Network Physiology
|March 17, 2023
Summary
Current exercise guidelines for cancer survivors are too general. A new Network Physiology approach personalizes exercise by considering individual responses and external factors for better health outcomes.
Area of Science:
- Exercise oncology
- Network physiology
- Personalized medicine
Background:
- Current American College of Sports Medicine (ACSM) exercise guidelines for cancer survivors are generic and do not account for individual variability.
- Individualization of exercise is currently based on a limited assessment of baseline physiological status and linear dose-response relationships.
- This approach fails to capture the complex acute and chronic responses to exercise at cellular and systemic levels.
Purpose of the Study:
- To propose a paradigm shift in exercise prescription for cancer survivors by adopting a Network Physiology approach.
- To highlight the limitations of current generic exercise guidelines.
- To advocate for a personalized, multi-system approach to exercise prescription.
Main Methods:
- Review of current exercise oncology guidelines and principles of network physiology.
- Conceptual framework integrating network physiology into exercise prescription.
- Discussion of the nonlinear dynamics of physiological responses to exercise.
Main Results:
- Network physiology offers a more comprehensive framework for understanding the body's response to exercise.
- A multi-system, person-centered approach can better target health outcomes by considering complex physiological interactions.
- External factors and internal physiological networks are crucial for effective exercise prescription.
Conclusions:
- A paradigm shift towards Network Physiology is needed for personalized exercise prescription in cancer survivors.
- This approach accounts for the interconnectedness of physiological systems and nonlinear dynamics.
- Personalized exercise, considering both internal and external factors, is essential for optimizing health outcomes in cancer survivors.
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