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The role of mesenchymal stem cell-derived EVs in diabetic wound healing

Min Jiang1, Xupin Jiang1, Hongmei Li2

  • 1Department of Plastic Surgery, State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China.

Frontiers in Immunology
|March 17, 2023
PubMed

Insights

Mesenchymal stem cell-derived extracellular vesicles (EVs) show promise for accelerating diabetic wound healing. These EVs offer a safer alternative to stem cell transplantation for treating diabetic foot complications.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Diabetes Research

Background:

  • Diabetic foot ulcers are a severe diabetes complication, often necessitating surgery and amputation.
  • Current treatments for diabetic foot wounds are limited, driving the need for novel therapeutic strategies.
  • Stem cell transplantation shows potential for wound healing but faces safety and clinical application challenges.

Purpose of the Study:

  • To review the current understanding of mesenchymal stem cell-derived extracellular vesicles (EVs) in promoting diabetic wound healing.
  • To explore the potential clinical applications of these EVs as a therapeutic approach.

Main Methods:

  • Literature review of studies on mesenchymal stem cell (MSC) derivatives and diabetic wound healing.
  • Analysis of the composition and function of extracellular vesicles (EVs).
  • Evaluation of the safety profile and therapeutic advantages of EVs compared to parental stem cells.

Main Results:

  • Mesenchymal stem cell (MSC) efficacy in wound healing is increasingly linked to their secreted EVs.
  • EVs facilitate intercellular communication through their cargo of RNA, DNA, and proteins.
  • EVs present a superior safety profile, avoiding immune responses, ethical concerns, and risks like embolism and carcinogenesis.

Conclusions:

  • Mesenchymal stem cell-derived EVs represent a promising cell-free therapeutic strategy for accelerating diabetic wound healing.
  • The inherent safety and efficacy of EVs warrant further investigation for clinical translation in managing diabetic foot complications.
Keywords:
angiogenesisdiabetes woundexosomesextracellular vesiclesmesenchymal stem cells

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