Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Waveguide-assisted plasmonic nanoparticle sensor using light scattering-based optical interrogation.

Nanotechnology·2026
Same author

Laser-Emitting Droplet Assay for Enzymatic Evaluation Applications.

ACS nano·2026
Same author

Local Birefringence Imaging by Similar Mueller Matrix Averaging Method in Catheter-Based Polarization-Sensitive Optical Coherence Tomography.

Chemical & biomedical imaging·2026
Same author

Deterministic radial displacement: modular, reconfigurable, and reusable.

Lab on a chip·2026
Same author

Portable and Point-of-Care Testing Approach for Determining Soil Extracellular Enzyme Activities.

Micromachines·2026
Same author

Tunable Particle Separation in a Straight Microchannel via Symmetrical Viscoelastic Sheath Flows.

Biosensors·2026

Related Experiment Video

Updated: Aug 6, 2025

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue
10:33

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue

Published on: February 3, 2023

1.3K

Autonomous Microlasers for Profiling Extracellular Vesicles from Cancer Spheroids.

Ziyihui Wang1,2, Guocheng Fang2, Zehang Gao3,4

  • 1School of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.

Nano Letters
|March 17, 2023
PubMed
Summary

Researchers developed self-propelled microlasers for sensitive biomarker detection in bodily fluids. These intelligent sensors amplify signals, enabling precise analysis of exosomes for cancer research and drug screening.

Keywords:
extracellular vesiclesliquid crystalmicrolaserself-propelled motorstumor spheroidswhispering gallery modes

More Related Videos

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
09:30

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

7.5K
A Macrophage-Tumor Spheroid Co-Invasion Assay
09:01

A Macrophage-Tumor Spheroid Co-Invasion Assay

Published on: January 24, 2025

698

Related Experiment Videos

Last Updated: Aug 6, 2025

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue
10:33

An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue

Published on: February 3, 2023

1.3K
Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
09:30

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

7.5K
A Macrophage-Tumor Spheroid Co-Invasion Assay
09:01

A Macrophage-Tumor Spheroid Co-Invasion Assay

Published on: January 24, 2025

698

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Optical Sensing

Background:

  • Self-propelled micro/nanomotors are advanced biosensors for detecting extracellular biomarkers in biological fluids.
  • Conventional luminescent motors face signal interference in dynamic biological environments, hindering biomarker characterization.
  • There is a need for enhanced sensing strategies to overcome signal limitations in complex biological samples.

Purpose of the Study:

  • To develop a novel strategy for amplifying subtle biomarker signals using light-matter interactions on micromotors.
  • To demonstrate a self-propelled whispering-gallery-mode microlaser capable of analyzing extracellular biomarkers.
  • To evaluate the sensing capabilities of this microlaser system in complex biological matrices.

Main Methods:

  • Fabrication of a liquid crystal microdroplet microlaser capable of autonomous propulsion.
  • Utilizing lasing spectral responses from cavity energy transfer for biomarker detection.
  • Coupling strong light-matter interactions to enhance signal sensitivity.
  • Testing the microlaser in a microfluidic biosystem with tumor-derived exosomes.

Main Results:

  • Demonstrated a self-propelled microlaser that effectively detects and quantifies protein biomarkers.
  • Generated exclusive molecular labels for exosome profiling from 3D multicellular cancer spheroids.
  • Showcased the system's capability to perform sensing in complex biological environments.

Conclusions:

  • The autonomous microlaser offers a promising approach for sensitive extracellular biomarker analysis.
  • This technology has potential applications in fundamental biological research, drug screening, cellular phenotyping, and organ-on-chip systems.