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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

496
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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[Genetic aspects involved in asthma].

Jorge Corona-Rivera1, Christian Peña-Padilla2, Guadalupe Elena Morales-Domínguez2

  • 1Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Departamento de Biología Mole-cular y Genómica, Instituto de Genética Humana Dr. Enrique Corona-Rivera, Guadalajara, Jalisco, México. rocorona@cucs.udg.mx.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|March 17, 2023
PubMed
Summary

Genetic factors significantly influence asthma development, interacting with environmental exposures. This review analyzes family, twin, and genomic studies to understand asthma

Keywords:
AsthmaCandidate regionsGWASGeneticsHeritabilityOmic studies

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Area of Science:

  • Pulmonology and Genetics

Context:

  • Asthma is a complex respiratory disease with diverse causes.
  • Understanding the interplay between genetic predisposition and environmental triggers is crucial for asthma research.

Purpose:

  • To review and synthesize current knowledge on the genetic underpinnings of asthma.
  • To explore the contributions of family aggregation, twin studies, candidate genes, genome-wide association studies (GWAS), and epigenomics to asthma pathophysiology.

Summary:

  • Analyzes family aggregation, twin concordance, and heritability studies to establish genetic influence in asthma.
  • Discusses findings from candidate gene and genome-wide association studies (GWAS) identifying specific genetic loci associated with asthma.
  • Highlights the role of epigenomics and other omics studies in elucidating gene-environment interactions in asthma development.

Impact:

  • Provides a comprehensive overview of genetic factors contributing to asthma.
  • Enhances understanding of asthma heterogeneity and pathophysiology.
  • Informs future research directions for personalized asthma management and prevention strategies.