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The association of preexisting severe asthma with COVID-19 outcomes
Paul D Terry1, R Eric Heidel2, Rajiv Dhand1
1Department of Medicine.
Insights
Patients with severe asthma may face increased risks for poor outcomes from coronavirus disease 2019 (COVID-19). However, current evidence is limited, necessitating further research to guide public health recommendations for asthma patients.
Area of Science:
- Pulmonology
- Infectious Diseases
- Epidemiology
Background:
- Most studies indicate asthma does not increase COVID-19 morbidity or mortality risk.
- The U.S. CDC suggests severe asthma patients may be vulnerable to COVID-19 complications.
- Understanding severe asthma's impact on COVID-19 outcomes is crucial for public health guidance.
Conclusions:
- An increased risk of poor COVID-19 outcomes in severe asthma patients is possible.
- Further high-quality evidence is required to clarify this association.
- Clear guidance for health agencies and asthma patients regarding COVID-19 risks is needed.
Purpose Of Review:
Three years after the emergence of coronavirus disease 2019 (COVID-19), many studies have examined the association between asthma and COVID-related morbidity and mortality, with most showing that asthma does not increase risk. However, the U.S. Centers for Disease Control (CDC) currently suggests that patients with severe asthma may, nonetheless, be particularly vulnerable to COVID-19-related morbidity.
Recent Findings:
With respect to poor COVID-19 outcomes, our search yielded nine studies that quantified associations with severe asthma, seven that considered use of monoclonal antibodies (mAB), and 14 that considered inhaled corticosteroids (ICS) use. mAb and ICS use have been used as measures of severe asthma in several studies. Severe asthma was significantly associated with poor COVID-19 outcomes. The results for mAb and ICS were mixed.
Summary:
An increased risk of poor COVID-19 outcomes in patients with severe asthma is possible. However, these studies remain sparse and suffer from several methodological limitations that hinder their interpretation. Additional evidence is needed to provide clear, cogent guidance for health agencies seeking to inform patients with asthma about potential risks due to COVID-19.
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