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Updated: Aug 6, 2025

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Published on: October 20, 2019
Mpox (Monkeypox) Infection During Pregnancy
Mindy M Sampson1, Gray Magee, Evan A Schrader
1Department of Internal Medicine, the Department of Obstetrics and Gynecology, and the Division of Infectious Diseases, Department of Pediatrics, Levine Children's Hospital, Atrium Health, Charlotte, and the Section on Infectious Diseases, Department of Internal Medicine, the Department of Pediatrics, and the Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Background:
An mpox (formerly "monkeypox") outbreak began in 2022, leading to infection in special populations, including pregnant individuals.
Case:
We present a case of an individual who presented with a labial ulcer and subsequent papular rash at 31 weeks of gestation. She was diagnosed with mpox infection and was treated with tecovirimat. She had an uncomplicated induction of labor at 39 2/7 weeks of gestation and delivered a healthy neonate. The neonate had a positive immunoglobulin G test result for orthopoxvirus but did not have skin lesions or positive molecular test results suggestive of infection.
Conclusion:
Transplacental transmission of mpox is possible, but, in this case, the neonate did not have clinical findings suggestive of active or antenatal mpox infection. Treatment with tecovirimat in gestational cases of mpox may be beneficial.
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