Related Experiment Video
Updated: Aug 6, 2025
Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
[A young woman with auto-immune pancreatitis]
Roeland Zoutendijk1,2, Hjalmar C van Santvoort3, Mihaela G Raicu4
1St. Antonius Ziekenhuis, Nieuwegein, Utrecht en Woerden. Afd. Maag-, Darm- en Leverziekten.
Background:
Acute pancreatitis is a frequently diagnosed disease. The majority is caused by cholelithiasis or alcohol. There are also two forms of auto-immune pancreatitis (AIP). Type 2 AIP presents on a younger age compared with IgG4 related pancreatitis. Clinical presentation as an acute pancreatitis, a mass in the pancreas or with jaundice. There is an association with inflammatory bowel disease.
Case Description:
A young patient with Crohn's disease developed abdominal pain compatible with acute pancreatitis. After exclusion of other etiologies a diagnosis of type 2 auto-immune pancreatitis was made with MRI/MRCP and typical histology. She was clinically successfully treated with steroids and follow up scan clearly showed improvement. Steroids were slowly withdrawn.
Conclusion:
Also young patients and patients with a normal IgG4 can have an AIP. Diagnosis is based on clinical, radiological and histological criteria. Type 2 AIP is treated with steroids without the need for maintenance therapy.
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