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Association between thyroid dysfunction and venous thromboembolism: A systematic review and meta-analysis.
Yunmeng Wang1, Chaowei Ding2, Chang Guo2
1Department of Cardiovascular Medicine, the Second Hospital of Hebei Medical University, Shijiazhuang, China.
Medicine
|March 17, 2023
Summary
Thyroid dysfunction, including hyperthyroidism and hypothyroidism, significantly increases the risk of venous thromboembolism (VTE). Routine thyroid function screening is recommended for individuals at high risk of VTE.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Hematology
Background:
- Thyroid dysfunction is a known factor in cardiovascular disease development.
- The association between thyroid dysfunction and venous thromboembolism (VTE) requires comprehensive investigation.
- Existing research presents conflicting data on the VTE risk associated with thyroid dysfunction.
Approach:
- A systematic meta-analysis was conducted, searching major databases (EMbase, PubMed, CNKI, Cochrane Library) up to October 2022.
- 10 articles comprising 15 studies on thyroid dysfunction and VTE were identified and analyzed.
- Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed- or random-effect models.
Key Points:
- Both subclinical and overt hyperthyroidism were associated with a statistically significant increased risk of VTE (OR 1.33, 95% CI: 1.29-1.38).
- Subclinical and overt hypothyroidism also demonstrated a significantly elevated risk of VTE (OR 1.52, 95% CI: 1.23-1.89).
- Sensitivity and bias analyses confirmed the increased VTE risk in both hyperthyroid and hypothyroid states (ORs 1.322 and 1.74, respectively).
Conclusions:
- Patients with thyroid dysfunction exhibit a heightened risk of developing venous thromboembolism.
- Routine thyroid function screening is advised for individuals identified as high-risk for VTE.
- This finding underscores the importance of managing thyroid health to mitigate VTE risk.
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