Related Experiment Video
Updated: Jul 16, 2026
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
Association between OLD and IBD: a systematic review and meta-analysis
Chaowei Ding1, Yunmeng Wang2, Tongxinwei Sun3
1Department of Respiratory and Critical Care Medicine, Xiamen Humanity Hospital of Fujian Medical University, Xiamen, Fujian, China.
Objective:
This study aimed to systematically evaluate the bidirectional association between obstructive lung diseases (OLD) [including chronic obstructive pulmonary disease (COPD), asthma, and bronchiectasis] and inflammatory bowel disease (IBD) [including Crohn's disease (CD) and ulcerative colitis (UC)].
Methods:
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a systematic search of the PubMed, Embase, and Cochrane Library databases to identify relevant observational studies published up to 30 June 2025. The included studies were cohort studies, case-control studies, and cross-sectional studies that reported relative risk (RR), hazard ratio (HR), or odds ratio (OR) with 95% confidence intervals (CIs). Study quality was assessed using the Newcastle-Ottawa Scale (NOS), and data were analyzed using random effects or fixed effects models. HRs, RRs, and ORs were analyzed separately according to the direction of association and the disease subtype.
Results:
A total of 30 observational studies were included. In the estimate-stratified analyses, IBD was associated with an increased risk of subsequent COPD, while COPD was generally associated with increased risks of subsequent CD and UC, although the COPD-to-CD and COPD-to-UC analyses showed substantial heterogeneity. For bronchiectasis, available evidence suggested a positive association with IBD; however, the pooled estimate for IBD and subsequent bronchiectasis was imprecise and should be interpreted with caution. For asthma, the association was more consistent: IBD was associated with an increased risk of subsequent asthma in both HR- and OR-based analyses, and asthma was also associated with subsequent IBD in the HR-based analysis. The bidirectional association was generally stronger and more consistent for CD than for UC.
Conclusion:
This systematic review and meta-analysis supports positive associations between OLD and IBD, particularly for COPD with the IBD subtypes and for asthma with IBD, especially CD. These associations should be interpreted according to the OLD subtype and the age context. Clinicians should be attentive to respiratory comorbidities in patients with IBD, and appropriate respiratory symptom assessment or screening may help early identification and management.
Systematic Review Registration:
https://www.crd.york.ac.uk/prospero/, identifier CRD420251169706.
Related Concept Videos
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
01:26Inflammatory Bowel Disease I: Introduction
01:20Inflammatory Bowel Disease IV: Clinical Manifestations