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Related Experiment Videos

Hyperammonemia associated with urethral obstruction in a dog.

J A Hall1, T A Allen, M J Fettman

  • 1Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.

Journal of the American Veterinary Medical Association
|November 1, 1987
PubMed
Summary

Hyperammonemia in a young dog was linked to a urinary tract infection, not liver issues. This suggests urinary stasis and specific bacteria can cause high ammonia levels in dogs without liver disease.

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Area of Science:

  • Veterinary Medicine
  • Canine Urology
  • Biochemistry

Background:

  • Hyperammonemia, elevated ammonia levels in the blood, is a serious condition in dogs.
  • Common causes include portal vascular anomalies and hepatic insufficiency.
  • Diagnosis in young dogs requires careful consideration of differential causes.

Observation:

  • A 10-week-old male Lhasa Apso presented with urethral obstruction and rupture.
  • Initial liver function tests were normal.
  • Staphylococcus sp. was isolated from the urine sample.

Findings:

  • The dog exhibited hyperammonemia despite normal liver function tests.
  • The presence of urea-splitting bacteria (Staphylococcus sp.) in the urine was noted.
  • This suggests a link between urinary stasis, infection, and hyperammonemia.

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Implications:

  • Urinary tract infections with urea-splitting organisms can cause hyperammonemia in dogs, even without apparent liver disease.
  • This finding expands the differential diagnosis for hyperammonemia in canine patients.
  • Highlights the importance of urinalysis and urine culture in cases of unexplained hyperammonemia.