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Updated: Aug 6, 2025
Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
Published on: November 27, 2016
Identification of Potent, Selective, and Peripherally Restricted Serotonin Receptor 2B Antagonists from a
Aaron M Bender1,2, Michael S Valentine3, Joshua A Bauer4,5
1Warren Center for Neuroscience Drug Discovery, Vanderbilt University, Franklin, Tennessee, USA.
Abstract:
Antagonists of the serotonin receptor 2B (5-HT2B) have shown great promise as therapeutics for the treatment of pulmonary arterial hypertension, valvular heart disease, and related cardiopathies. Herein, we describe a high-throughput screen campaign that led to the identification of highly potent and selective 5-HT2B antagonists. Furthermore, selected compounds were profiled for their predicted ability to cross the blood-brain barrier. Two exemplary compounds, VU0530244 and VU0631019, were predicted to have very limited potential for brain penetration in human subjects, a critical profile for the development of 5-HT2B antagonists devoid of centrally-mediated adverse effects.
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