Natural flavonoids alleviate glioblastoma multiforme by regulating long non-coding RNA.

Area of Science:

• Neuro-oncology
• Molecular Biology
• Pharmacology

Background:

• Glioblastoma multiforme (GBM) is an aggressive adult primary brain tumor with a median survival rate under one year.
• Novel therapeutic strategies are urgently needed for GBM treatment and prevention.
• Flavonoids, natural compounds with diverse biological functions, are emerging as potential anti-cancer agents.

Purpose of the Study:

• To review the role of long non-coding RNAs (lncRNAs) in GBM progression.
• To explore the influence of flavonoids on lncRNA regulation in GBM.
• To highlight the potential of flavonoids as a novel treatment for GBM.

Main Methods:

• Literature review focusing on studies investigating flavonoids, lncRNAs, and GBM.
• Analysis of molecular mechanisms by which flavonoids impact GBM via lncRNA regulation.
• Synthesis of evidence on flavonoid-mediated effects on GBM hallmarks.

Main Results:

• Flavonoids regulate epigenetic modifications, transcription, and microRNA (miRNA) expression in GBM through lncRNAs.
• Flavonoids can induce apoptosis and autophagy in GBM cells by modulating lncRNA.
• Flavonoids improve GBM metabolic abnormalities, influence the tumor microenvironment, inhibit angiogenesis, and block tumor initiation, growth, and metastasis.

Conclusions:

• Flavonoids demonstrate significant potential in targeting GBM progression through lncRNA regulation.
• Flavonoid-mediated modulation of lncRNAs offers a promising avenue for novel GBM prevention and treatment strategies.
• Further research into flavonoids and lncRNAs could lead to improved patient prognosis for GBM.