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Cord blood grafts for patients with HIV?
1Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cell
|March 17, 2023
Abstract:
Since CCR5 is a key co-receptor for HIV entry into cells, replacing an HIV patient's cells with CCR5-deficient cells is thought to protect the new hematopoietic/immune system from infection. In this issue of Cell, Hsu et al. show that transplanting a cord blood graft carrying the CCR5Δ32 mutation led to a durable HIV remission in a patient with HIV and leukemia.
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