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Related Concept Videos

Allergic Reactions02:06

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
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Microneedle array patches for allergen-specific immunotherapy.

Juan L Paris1, Lalitkumar K Vora2, María José Torres3

  • 1Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain; School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, UK.

Drug Discovery Today
|March 17, 2023
PubMed
Summary
This summary is machine-generated.

Allergen-specific immunotherapy (AIT) faces challenges with current delivery methods. Microneedles offer a promising strategy to enhance AIT efficacy and safety by improving therapeutic delivery into the skin.

Keywords:
allergyimmunotherapymicroneedles

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Area of Science:

  • Immunology
  • Dermatology
  • Biotechnology

Background:

  • Allergies are increasingly prevalent globally.
  • Allergen-specific immunotherapy (AIT) is the only curative treatment for allergies, inducing long-term tolerance.
  • Current AIT methods have limitations in efficacy and safety due to administration routes.

Purpose of the Study:

  • To review recent advancements in using microneedles for allergen-specific immunotherapy (AIT).
  • To explore the potential of microneedle technology to overcome current AIT limitations.
  • To identify future research directions for microneedle-based AIT.

Main Methods:

  • Review of current literature on microneedle technology and AIT.
  • Analysis of skin barrier properties and immune cell distribution in the skin.
  • Evaluation of microneedle-based delivery systems for allergens.

Main Results:

  • The skin's immune microenvironment is suitable for immunotherapy.
  • The stratum corneum presents a significant barrier to transdermal drug delivery.
  • Microneedles show potential to enhance allergen penetration and immune cell interaction in the skin.

Conclusions:

  • Microneedles represent a promising approach to improve AIT delivery and efficacy.
  • Further research is needed to optimize microneedle design and allergen formulation for AIT.
  • Microneedle-based AIT could offer a safer and more effective treatment option for allergic diseases.