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Updated: Aug 6, 2025

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

Cerebral Amyloid Angiopathy.

Laszlo Szidonya¹, Joshua P Nickerson²

¹Diagnostic Radiology, Oregon Health & Science University, L340, 3245 Southwest Pavilion Loop, Portland, OR 97239, USA; Diagnostic Radiology, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.

Radiologic Clinics of North America

|March 17, 2023

Summary

This summary is machine-generated.

Cerebral amyloid angiopathy (CAA) involves amyloid protein buildup in brain blood vessels, increasing hemorrhage risk. Early detection via imaging like CT, SWI, or PET is crucial for managing this age-related condition.

Keywords:

Amyloid Cerebral amyloid angiopathy MR imaging Microhemorrhage Positron emission tomography

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Isolation and Cannulation of Cerebral Parenchymal Arterioles

Isolation and Cannulation of Cerebral Parenchymal Arterioles

Published on: May 23, 2016

Area of Science:

Neurology
Neuroradiology
Pathology

Background:

Cerebral amyloid angiopathy (CAA) is characterized by amyloid protein deposition in intracranial arteries.
It is primarily sporadic and its prevalence increases with age.
CAA is linked to a higher risk of cerebral hemorrhages, including lobar and subarachnoid types.

Purpose of the Study:

To summarize the key aspects of cerebral amyloid angiopathy.
To highlight the diagnostic imaging modalities for CAA.
To emphasize the association between CAA and cerebrovascular events.

Main Methods:

Review of the pathophysiology and clinical presentation of CAA.
Discussion of diagnostic findings on computed tomography (CT) and susceptibility-weighted imaging (SWI).
Mention of emerging positron emission tomography (PET) radiotracers for amyloid detection.

Main Results:

Amyloid deposition in cerebral vessels is the hallmark of CAA.
Peripheral lobar hemorrhages on CT and susceptibility artifacts/superficial siderosis on SWI are indicative of CAA in elderly patients.
SWI is highly sensitive for detecting microhemorrhages associated with CAA.

Conclusions:

CAA is a significant cause of intracerebral hemorrhage, particularly in the elderly.
Advanced neuroimaging techniques, including CT, SWI, and PET, are vital for diagnosing CAA.
Understanding CAA is critical for managing patients at risk of or presenting with related cerebrovascular pathologies.