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Precision of morphogen-driven tissue patterning during development is enhanced through contact-mediated cellular

Chandrashekar Kuyyamudi1,2, Shakti N Menon1, Sitabhra Sinha1,2

  • 1The Institute of Mathematical Sciences, CIT Campus, Taramani, Chennai 600113, India.

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Summary

Developing embryos achieve consistent cell fates despite fluctuating signals. Local cell interactions create a bimodal gene response, reducing uncertainty in developmental boundaries.

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Area of Science:

  • Developmental biology
  • Cellular signaling
  • Systems biology

Background:

  • Embryonic development relies on cells attaining location-specific fates.
  • Morphogen gradients provide positional information, but are subject to fluctuations.
  • Molecular interpretation of morphogen signals can also vary.

Purpose of the Study:

  • To investigate how developing embryos achieve robust cell differentiation despite signal noise.
  • To elucidate the role of cell-cell interactions in developmental patterning.
  • To understand the mechanisms reducing uncertainty in fate determination.

Main Methods:

  • Modeling of gene regulatory networks incorporating cell-cell interactions.
  • Analysis of the response dynamics of patterning genes to morphogen signals.
  • Investigating the impact of inherent asymmetry in gene response.

Main Results:

  • Local, contact-mediated cell-cell interactions lead to a bimodal response in patterning genes.
  • This bimodal response is driven by inherent asymmetry in gene sensitivity to morphogen signals.
  • Consistent cell identity is achieved by a dominant gene response, reducing boundary uncertainty.

Conclusions:

  • Cell-cell interactions are crucial for robust pattern formation in developing embryos.
  • Inherent asymmetry in gene responses, coupled with local interactions, ensures developmental precision.
  • This mechanism significantly reduces uncertainty in establishing boundaries between distinct cell fates.